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The work is newly published in Nature Chemistry. The Eisenberg lab has long focused on why normal proteins convert to a toxic state in prion diseases, amyloidoses, and tauopathies, causing neurodegeneration and dementia. The lab also studies whether these diseases are transmissible from cell to cell or among organisms.
Axons are the long tails of neurons that connect with other neurons to build a communications network over which brain signals travel. They also envisioned a prion-like role for toxic strains of converted tau, suspecting them of seeding additional tau conversion Nelson et al, Nature, The new discovery by Seidler et al also draws upon the steric zipper concept; they describe how any tau molecule can bind two others by virtue of these zippers.
Once interfaced with each other in this way, segments of tau create an interlocking structure that could possibly represent the start of fibril formation and spread to other neurons.
In all, three different zipper structures were discovered. Seidler used a cutting-edge technique called cryo-electron microscopy to image these nanostructures within tau molecules. Earlier this year, the Nobel Prize in chemistry was given to the scientists who developed cryo-electron microscopy, which uses samples frozen at liquid-nitrogen temperatures.
In biosensor cell lines developed by a former BrightFocus grantee, Marc Diamond, MD, the UCLA team found that one of their inhibitors effectively blocked the spread of tau aggregation which is thought by many to drive the progression of AD.
A start-up company he co-founded is working to develop their top compound for further investigation and testing. This content was first posted on: December 13, About the Author Full Bio The information provided in this section is a public service of BrightFocus Foundation, and should not in any way substitute for the advice of a qualified healthcare professional, and is not intended to constitute medical advice.
Although we take efforts to keep the medical information on our website updated, we cannot guarantee that the information on our website reflects the most up-to-date research. Please consult your physician for personalized medical advice; all medications and supplements should only be taken under medical supervision.
BrightFocus Foundation does not endorse any medical product or therapy. Some of the content in this section is adapted from other sources, which are clearly identified within each individual item of information.“BrightFocus Foundation has funded, and continues to fund, many of these scientists who were key in making these discoveries.
With its support, I am excited to be in a position where I can now design and test strategies and agents to combat this disease. omics group has scheduled its , and international and scientific conferences, meetings, events, workshops and symposiums in america, europe, asia.
The U.S. Food and Drug Administration today announced a new comprehensive plan for tobacco and nicotine regulation that will serve as a multi-year roadmap to better protect kids and significantly reduce tobacco-related disease and death.
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Its also important to know the source of the data and other caveats. Results from a new study may lead to approval of what could be the first drug that ameliorates potentially deadly reactions in children with severe peanut allergies. Abstract The NO/ONOO− cycle is a biochemical vicious cycle that is thought to cause such diseases as chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), multiple chemical sensitivity (MCS), fibromyalgia (FM), and possibly a large number of other chronic inflammatory diseases.